The English cast has been announced for the Dororo anime:
- Chaney Moore is Dororo
- Adam Gibbs is Hyakkimaru
- Blake Jackson is Tahomaru
- James Belcher is Biwamaru
- David Wald is Daigo Kagemitsu
- Patricia Duran is Nuinokata
- Andrew Love is Hyogo
- Elissa Cuellar is Mutsu
- Ty Mahany is Jukai
- Antonio Lasanta is Kaname
- Orlanders Tao Jones is Sabu
- John Gremillion is Denkichi
- Joanne Bonasso is Bandai
- Kyle Colby Jones is Kanekozo and Doshu
- Gabriel Regojo is Daigo Spy
- Avery Smithhart is Osushi
- Joe Daniels is Tanosuke
- Luci Christian is Mio and Sukeroku
- Brittney Karbowski is Take
- Rob Mungle is Daigo Commander
- Christine Auten is Ohagi
- John Swasey is Yajiro
- Kira Vincent-Davis is Saru
- Heidi Hinkel is Oume
- Josh Morrison is Hibukuro
- Melissa Engler is Ojiya
- Greg Cote is Itachi
- Molly Searcy is Okaka
- Jay Hickman is Lord Sabame
- Kalin Coates is Yokai Kozo
- Josh Grelle is Shiranui
- Jad Saxton is Okowa
- Jason Douglas is Munetsuna and Narrator
- Jeremy Gee is Saburota
- Sean Patrick Judge is Yahiko
- Holly Segarra is Sakichi
- Dave Harbold is Lord Asakura
- Adam Noble is Jiheita
Additional cast includes: Julia Oliver-Touchstone, Shelley Calene-Black, Jay Hickman, Maggie Flecknoe, Carl Masterson, Houston Hayes, Shannon Reed, Allison Sumrall, Ned Gayle, Lebraska Washington, Ricardo Contreras, John Gremillion, Stephen Fenley, Joel McCray, Jovan Jackson, Blake Weir, and Christina Kelly.
Kyle Colby Jones is directing the dub.
Sentai Filmworks licensed the anime in the United States, Canada, the United Kingdom, Australia, New Zealand, South Africa, Latin America, Spain, Portugal, the Netherlands, and Nordic and Scandinavian countries. The company will release the series on home video, including Blu-ray and digital sell through, starting on June 29, 2021.
