The main cast has been announced for the forthcoming Hisone to Masotan anime:
- Misaki Kuno is Hisone Amakasu
- Tomoyo Kurosawa is Nao Kaizaki
- Maki Kawase is El Hoshino
- Satomi Arai is Liliko Kinutsugai
- Kaori Nazuka is Mayumi Hitomi
- Romi Park is Sada Hinomoto
- Yuuki Kaji is Haruto Okonogi
- Yukitoshi Tokumoto is Yutaka Zaito
- Rie Kugimiya is Remi Kakiyasu
- Junichi Suwabe is Hiroki Ikushima
- Jouji Nakata is Hiroshi Sosoda
Shinji Higuchi is supervising the anime for Warner Brothers. Hiroshi Kobayashi is directing the anime at BONES, and Mari Okada is writing the anime. Higuchi noted that he, BONES, and Okada created the original story concept together.
Yoshiyuki Ito the original character designs by Toshinao Aoki for animation. Taisei Iwasaki is composing the music.
Hisone to Masotan is scheduled to premiere on Japanese television in April 2018.